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The First and Only Weekly Auto-Injector

Time to Rethink Testosterone.

One Click. Once a Week.

XYOSTED® is a prescription medicine that contains testosterone. XYOSTED® is used to treat adult men who have low or no testosterone due to certain medical conditions.

XYOSTED® is contained within a ready-to-use auto-injector, which means you can inject without having to prepare a syringe.

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Precision Testosterone Delivery

Looking for a different injectable testosterone experience?

  • Available in 3 Dose Strengths
    50

    mg

    75

    mg

    100

    mg

    Recommended Starting Dose

  • Route
    Subcutaneous (under skin)
  • Frequency
    Weekly administration
  • Location
    Self-administered at home
  • Patients
    Hypogonadal men, 18+
  • Injection Duration
    Only 10 seconds to
    inject**
**Not including preparation of injection site and disposal time
product
product
¶ Based on Symphony
national data METYS (TRx),
Jan 2025 to Dec 2025. Data on
file. Antares Pharma, Inc.;
2026.
Precision Testosterone Delivery

Looking for a different injectable testosterone experience?

Unlike TRT Injected into the muscle, XYOSTED® is administered subcutaneously into the fat layer just under the skin of your abdomen - with 99.4% of injections reported to be pain-free.*†

*150 patients entered the one-year trial; 99.4% of injections were reported to be pain free.
†Injection site reactions, including bruising, bleeding, redness, and hardness, were reported in 12.7% of patients who received XYOSTED for up to 1 year in the trial. No patients discontinued XYOSTED because of injection site reactions.

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Clinical Evidence

Steady Testosterone Levels
Week-After-Week.1,2,3*

  • 99.4%

    99.4% of injections are reported to be pain-free*

    *150 patients entered the one-year trial; 99.4% of injections were reported to be pain free. †Injection site reactions, including bruising, bleeding, redness, and hardness, were reported in 12.7% of patients who received XYOSTED for up to 1 year in the trial. No patients discontinued XYOSTED because of injection site reactions.

  • 98.5%

    98.5% of patients who underwent PK assessment achieved physiologic levels at week 121

    1Studied for 52 weeks when taken every week as directed. Achieving desired blood levels may require dose adjustments at Week 7 based upon Week 6 blood levels. Some patients fell below minimum level of 300 ng/dL despite dose adjustments. 150 patients entered the study; 137 completed 12 weeks of treatment.

  • 9/10

    9 out of 10 men were within normal range by week 12‡

    ‡in a clinical study of 150 patients on XYOSTED 90% had testosterone levels in the normal range by week 12. Studied for 52 weeks when taken every week as directed. Achieving desired blood levels may require dose adjustments at Week 7 based upon Week 7 blood levels. Some patients fell below minimum level of 300 ng/dL despite dose adjustments. Normal range was defined as 300-1,100 ng/dL.

  • 6weeks

    Steady state by 6 weeks
    (553 +/- 127 ng/mL)3

    3 Data on File. XYO-0025. Antares Pharma, Inc.
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1 Kaminetsky JC et al J Urol. 2019;201:587-594. | 2 Data on File. XYO-0024. Antares Pharma, Ewing, N.J. | 3 Data on File. XYO-0025. Antares Pharma, Inc.

One Click. Once a Week.

A Fast, Virtually Painless Injection.*

Self-administered at home. Once weekly TRT auto-injector. Only 10 seconds to inject.**
One Click. Once a Week.

A Fast, Virtually Painless Injection.*

Self-administered at home. Once weekly TRT auto-injector. Only 10 seconds to inject.**
*150 patients entered the one-year trial; 99.4% of injections were reported to be pain free.
**Not including preparation of injection site and disposal time
XYOSTED® is designed for precise administration. With built-in flexibility, patients can discreetly self-administer at home, reducing the need for in-office visits.
  • Ready-to-use auto-injector
  • Hidden 27-gauge needle
  • Subcutaneous injection depth
  • Press-activated injection
  • Prefilled, fixed dosing
  • No refrigeration required
Do not refrigerate or freeze. Use at room temperature. Store at controlled room temperature, 68°F to 77°F (20°C to 25°C). Protect from light (keep in carton until time of use). Keep XYOSTED and all medicines out of the reach of children.
See if XYOSTED® is right for you See if XYOSTED® is right for you
Actor portrayal.
A DIFFERENT TRT EXPERIENCE

Taking XYOSTED®

These are not complete instructions. See the complete Instructions for Use. Your healthcare provider will show you or your caregiver how to inject XYOSTED®. You should not inject XYOSTED® until you have been trained on the proper way to use it.

One click. Once a week. Always ready to use. XYOSTED® is injected into the fat layer just under the skin of your abdomen using an auto-injector.

  • step 1

    Remove Cap

    Twist the Cap to remove (this will also break the red safety seal)

  • step 2

    Position Auto-Injector

    Gently squeeze the abdomen injection site to create a raised area and hold that area firmly until after the injection is complete

  • step 3

    Inject & Hold Down

    Firmly push the Auto-Injector down on the abdomen site and continue to hold it down after you hear the “CLICK”

  • step 4

    Inspect Viewing Window

    After injecting, inspect the Viewing Window. It should be orange, confirming the dose was administered

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See if XYOSTED® is right for you See if XYOSTED® is right for you

One Click. Once a Week.

XYOSTED® is now available
through LifeMD®

LifeMD® offers a comprehensive plan for long-term TRT treatment. Get transparent, ongoing care with a personalized treatment plan and support — built around how you actually live.
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Get started with LifeMD® for:

Labs are required before any prescription can be written. Have recent bloodwork within 6 months? You may be able to skip new labs and book your consult directly. A LifeMD® provider may prescribe XYOSTED® if clinically appropriate. Medication cost is separate.
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Based on Symphony national data METYS (TRx), Jan 2025 to Dec 2025. Data on file. Antares Pharma, Inc.; 2026.
PATIENT TESTIMONIALS

Patient-Focused
Treatment Experience.

Actor portrayal

"XYOSTED is the right tool for me because I get steady testosterone levels from a device that helps simplify injecting for me."

Auto mechanic • 15 years on TRT •2 years on XYOSTED Kevin, 52
Actor portrayal

"Having consistent levels reinforces why I'm consistent with my therapy."

Automotive engineer • 10 years on TRT, 2 years on XYOSTED Lonnie, 54
Actor portrayal

"I had been on gel for two years. My wife was always worried about the transfer risk — we have young kids. XYOSTED® solved that completely. No precautions at home. It was a no-brainer once I learned about it."

Switched from testosterone gel • Father of 2 Marcus, 46
Actor portrayal

"It's ready to use, and that helps me stay consistent with my injections."

Contract security • 15 years on TRT, 1.5 years on XYOSTED Joe, 48
Actor portrayal

"There's a practicality to XYOSTED that helps me stay on a regular weekly injection schedule."

Video game publisher • New to TRT via XYOSTED Jeff, 44
Actor portrayal

"XYOSTED is the right tool for me because I get steady testosterone levels from a device that helps simplify injecting for me."

Auto mechanic • 15 years on TRT •2 years on XYOSTED Kevin, 52
Actor portrayal

"Having consistent levels reinforces why I'm consistent with my therapy."

Automotive engineer • 10 years on TRT, 2 years on XYOSTED Lonnie, 54
Actor portrayal

"I had been on gel for two years. My wife was always worried about the transfer risk — we have young kids. XYOSTED® solved that completely. No precautions at home. It was a no-brainer once I learned about it."

Switched from testosterone gel • Father of 2 Marcus, 46
Actor portrayal

"It's ready to use, and that helps me stay consistent with my injections."

Contract security • 15 years on TRT, 1.5 years on XYOSTED Joe, 48
Actor portrayal

"There's a practicality to XYOSTED that helps me stay on a regular weekly injection schedule."

Video game publisher • New to TRT via XYOSTED Jeff, 44
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Reviews shown are from verified XYOSTED® patients. Photos are for illustrative purposes only.

Frequently Asked
Questions

Frequently
Asked
Questions

Ready to upgrade your TRT experience?

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XYOSTED is a prescription medicine used to treat adult men who have low or no testosterone due to certain medical conditions. It is not known if XYOSTED is safe and effective for use in children younger than 18 years old or for the treatment of men who have low testosterone due to aging. Improper use of XYOSTED may affect bone growth in children.

Your doctor will diagnose hypogonadism based on a combination of your symptoms and laboratory testing. A diagnosis of low testosterone is confirmed by at least two separate early morning blood tests showing total testosterone levels below 300 ng/dL.

In a clinical study of 150 patients on XYOSTED*, 90% had testosterone levels in the normal range† by week 12. Individual results may vary.

* Studied for 52 weeks when taken every week as directed. Achieving desired blood levels may require dose adjustments at Week 7 based upon Week 6 blood levels. Some patients fell below minimum level of 300ng/dL despite dose adjustments.
† “Normal Range” is defined as 300-1,100 ng/dL.

The most common side effects are increased hematocrit, hypertension, increased PSA, injection site bruising, headaches, back pain, increased blood creatine phosphokinase, and injection site hemorrhage, each of which occurred in fewer than 15% of participants in two clinical studies in a total of 283 men who received XYOSTED once a week for up to one year. Please refer to the Important Safety Information for full Warnings and Precautions.

In a one-year clinical trial of 150 men receiving 1,519 injections, 99.4% of injections were reported as painless. Injection site reactions can occur, including: bruising, bleeding, redness, and hardness in 12.7% of study patients at one time during the 52 week study period.

The needle in the XYOSTED auto-injector is not visible before or during injection. The device is designed to be user-friendly and discreet, with a collar-activated mechanism that hides the needle.

Yes, you can travel with XYOSTED.* Be sure to pack it in your carry-on luggage if you’re flying. You may also want to bring a copy of your prescription and a letter from your doctor to help with airport security.

* Store XYOSTED at room temperature (68°F to 77°F or 20°C to 25°C). Do not refrigerate or freeze. Keep it in the original packaging to protect it from light and out of reach of children.

You will need to contact your insurance provider to find out if you are covered.

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION AND INDICATION

It is not known if XYOSTED is safe and effective for use in children younger than 18 years old or for men who have low testosterone due to aging.

Do not use XYOSTED if you:

  • Are a man who has breast cancer.
  • Have or might have prostate cancer.
  • Are a woman who is pregnant. XYOSTED may harm your unborn baby.
  • Are allergic to XYOSTED or to any ingredients in XYOSTED including testosterone or sesame oil.

What should I tell my healthcare provider before using XYOSTED?

Before you use XYOSTED, tell your healthcare provider about all of your medical conditions, including, if you have any of the following:

High blood pressure or are being treated for high blood pressure, or have heart problems, high red blood cell count, or high hemoglobin laboratory value, urinary problems due to an enlarged prostate, kidney or liver problems, a history of mental health illness including suicidal thoughts or actions, depression, anxiety or mood disorder, or problems breathing while you sleep (sleep apnea). Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using XYOSTED with other medicines can affect each other. Especially, tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), corticosteroids or medicines for pain and cold. Know the medicines you take. Ask your pharmacist for a list of all your medicines if you are not sure. Show your list to your healthcare provider and pharmacist when you get a new medicine.

How should I use XYOSTED?

  • See the detailed Instructions for Use for Information about how to use XYOSTED.
  • Use XYOSTED exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will show you or your caregiver how to inject XYOSTED. You should not inject XYOSTED until you have been trained on the proper way to use it.

What are the possible side effects of XYOSTED?

XYOSTED can cause serious side effects including:

  • Increase in red blood cell count, hematocrit or hemoglobin. High red blood cell counts increase the risk of clots, strokes, and heart attacks. You may need to stop XYOSTED if your red blood cell count increases. Your healthcare provider should check your red blood cell count, hematocrit and hemoglobin while you use XYOSTED.
  • If you already have an enlarged prostate, your signs and symptoms may get worse while using XYOSTED. This can include: increased nighttime urination, trouble starting urination, more frequent urination, feeling an urge to urinate, having a urine accident, and being unable to pass urine or weak urine flow
  • Increased risk of prostate cancer. Your healthcare provider should check you for prostate cancer or any other prostate problems before you start and while you use XYOSTED.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include leg pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Increase in blood pressure. XYOSTED can increase your blood pressure. Increases in blood pressure can increase the risk of heart attack or stroke over time. If your blood pressure increases while on XYOSTED, blood pressure medicines may need to be started. If you are taking blood pressure medicines, new blood pressure medicines may need to be added or your current blood pressure medicines may need to be adjusted to control your blood pressure. If your blood pressure cannot be controlled, XYOSTED may need to be stopped. Your healthcare provider will monitor your blood pressure while you are being treated with XYOSTED.
  • Abuse. Testosterone can be abused, when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses XYOSTED may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine or pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body, with or without heart failure. This may cause serious problems for people who have heart, kidney or liver disease.
  • Enlarged or painful breasts.
  • Problems breathing while you sleep (sleep apnea).
  • Change in mood. Talk to your healthcare provider if you have changes in mood or behavior including, new or worsening depression, or suicidal thoughts.

Call your healthcare provider right away if you have any of the serious side effects listed above.

  • The most common side effects of XYOSTED include: red blood cell increase, prostatic specific antigen (PSA) increase (a blood test for prostate cancer), high blood pressure, and injection site reactions including bruising, bleeding, redness and headache.
  • Other side effects include more erections than are normal for you or erections that last a long time. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XYOSTED. For more information, ask your healthcare provider or pharmacist.

INDICATION/WHAT IS XYOSTED?

XYOSTED is a prescription medicine that contains testosterone. XYOSTED is used to treat adult men who have low or no testosterone due to certain medical conditions. It is not known if XYOSTED is safe and effective for use in children younger than 18 years old. Improper use of XYOSTED may affect bone growth in children. It is not known if XYOSTED is safe or effective to treat men who have low testosterone due to aging. XYOSTED is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Keep your XYOSTED in a safe place to protect it. Never give your XYOSTED to anyone else. Selling or giving away this medicine may harm others and it is against the law.

XYOSTED is not meant for use by women.

For more information, go to www.XYOSTED.com
or call 1-844-XYOSTED (1-844-996-7833).
To report side effects to the FDA,
visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see the full Prescribing Information and Medication Guide.
August 2025 Update.

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION AND INDICATION

It is not known if XYOSTED is safe and effective for use in children younger than 18 years old or for men who have low testosterone due to aging.

Do not use XYOSTED if you:

  • Are a man who has breast cancer.
  • Have or might have prostate cancer.
  • Are a woman who is pregnant. XYOSTED may harm your unborn baby.
  • Are allergic to XYOSTED or to any ingredients in XYOSTED including testosterone or sesame oil.

What should I tell my healthcare provider before using XYOSTED?

Before you use XYOSTED, tell your healthcare provider about all of your medical conditions, including, if you have any of the following:

High blood pressure or are being treated for high blood pressure, or have heart problems, high red blood cell count, or high hemoglobin laboratory value, urinary problems due to an enlarged prostate, kidney or liver problems, a history of mental health illness including suicidal thoughts or actions, depression, anxiety or mood disorder, or problems breathing while you sleep (sleep apnea). Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Using XYOSTED with other medicines can affect each other. Especially, tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), corticosteroids or medicines for pain and cold. Know the medicines you take. Ask your pharmacist for a list of all your medicines if you are not sure. Show your list to your healthcare provider and pharmacist when you get a new medicine.

How should I use XYOSTED?

  • See the detailed Instructions for Use for Information about how to use XYOSTED.
  • Use XYOSTED exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will show you or your caregiver how to inject XYOSTED. You should not inject XYOSTED until you have been trained on the proper way to use it.

What are the possible side effects of XYOSTED?

XYOSTED can cause serious side effects including:

  • Increase in red blood cell count, hematocrit or hemoglobin. High red blood cell counts increase the risk of clots, strokes, and heart attacks. You may need to stop XYOSTED if your red blood cell count increases. Your healthcare provider should check your red blood cell count, hematocrit and hemoglobin while you use XYOSTED.
  • If you already have an enlarged prostate, your signs and symptoms may get worse while using XYOSTED. This can include: increased nighttime urination, trouble starting urination, more frequent urination, feeling an urge to urinate, having a urine accident, and being unable to pass urine or weak urine flow
  • Increased risk of prostate cancer. Your healthcare provider should check you for prostate cancer or any other prostate problems before you start and while you use XYOSTED.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include leg pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Increase in blood pressure. XYOSTED can increase your blood pressure. Increases in blood pressure can increase the risk of heart attack or stroke over time. If your blood pressure increases while on XYOSTED, blood pressure medicines may need to be started. If you are taking blood pressure medicines, new blood pressure medicines may need to be added or your current blood pressure medicines may need to be adjusted to control your blood pressure. If your blood pressure cannot be controlled, XYOSTED may need to be stopped. Your healthcare provider will monitor your blood pressure while you are being treated with XYOSTED.
  • Abuse. Testosterone can be abused, when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses XYOSTED may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine or pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body, with or without heart failure. This may cause serious problems for people who have heart, kidney or liver disease.
  • Enlarged or painful breasts.
  • Problems breathing while you sleep (sleep apnea).
  • Change in mood. Talk to your healthcare provider if you have changes in mood or behavior including, new or worsening depression, or suicidal thoughts.

Important Safety Information

Last Updated: June 23, 2026

 

IMPORTANT SAFETY INFORMATION

It is not known if XYOSTED is safe and effective for use in children younger than 18 years old or for men who have low testosterone due to aging.

Do not use XYOSTED if you:

  • Are a man who has breast cancer.
  • Have or might have prostate cancer.
  • Are a woman who is pregnant. XYOSTED may harm your unborn baby.
  • Are allergic to XYOSTED or to any ingredients in XYOSTED including testosterone or sesame oil.

What should I tell my healthcare provider before using XYOSTED?

Before you use XYOSTED, tell your healthcare provider about all of your medical conditions, including, if you have any of the following:

High blood pressure or are being treated for high blood pressure, or have heart problems, high red blood cell count, or high hemoglobin laboratory value, urinary problems due to an enlarged prostate, kidney or liver problems, a history of mental health illness including suicidal thoughts or actions, depression, anxiety or mood disorder, or problems breathing while you sleep (sleep apnea).

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Using XYOSTED with other medicines can affect each other. Especially, tell your healthcare provider if you take insulin, medicines that decrease blood clotting (blood thinners), corticosteroids or medicines for pain and cold. Know the medicines you take. Ask your pharmacist for a list of all your medicines if you are not sure. Show your list to your healthcare provider and pharmacist when you get a new medicine.

How should I use XYOSTED?

  • See the detailed Instructions for Use for Information about how to use XYOSTED.
  • Use XYOSTED exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will show you or your caregiver how to inject XYOSTED. You should not inject XYOSTED until you have been trained on the proper way to use it.

What are the possible side effects of XYOSTED?

XYOSTED can cause serious side effects including:

  • Increase in red blood cell count, hematocrit or hemoglobin. High red blood cell counts increase the risk of clots, strokes, and heart attacks. You may need to stop XYOSTED if your red blood cell count increases. Your healthcare provider should check your red blood cell count, hematocrit and hemoglobin while you use XYOSTED.
  • If you already have an enlarged prostate, your signs and symptoms may get worse while using XYOSTED. This can include: increased nighttime urination, trouble starting urination, more frequent urination, feeling an urge to urinate, having a urine accident, and being unable to pass urine or weak urine flow.
  • Increased risk of prostate cancer. Your healthcare provider should check you for prostate cancer or any other prostate problems before you start and while you use XYOSTED.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include leg pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Increase in blood pressure. XYOSTED can increase your blood pressure. Increases in blood pressure can increase the risk of heart attack or stroke over time. If your blood pressure increases while on XYOSTED, blood pressure medicines may need to be started. If you are taking blood pressure medicines, new blood pressure medicines may need to be added or your current blood pressure medicines may need to be adjusted to control your blood pressure. If your blood pressure cannot be controlled, XYOSTED may need to be stopped. Your healthcare provider will monitor your blood pressure while you are being treated with XYOSTED.
  • Abuse. Testosterone can be abused, when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses XYOSTED may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine or pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body, with or without heart failure. This may cause serious problems for people who have heart, kidney or liver disease.
  • Enlarged or painful breasts.
  • Problems breathing while you sleep (sleep apnea).
  • Change in mood. Talk to your healthcare provider if you have changes in mood or behavior including, new or worsening depression, or suicidal thoughts.

Call your healthcare provider right away if you have any of the serious side effects listed above.

  • The most common side effects of XYOSTED include: red blood cell increase, prostatic specific antigen (PSA) increase (a blood test for prostate cancer), high blood pressure, and injection site reactions including bruising, bleeding, redness and headache.
  • Other side effects include more erections than are normal for you or erections that last a long time. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XYOSTED. For more information, ask your healthcare provider or pharmacist.

INDICATION/WHAT IS XYOSTED?

XYOSTED is a prescription medicine that contains testosterone. XYOSTED is used to treat adult men who have low or no testosterone due to certain medical conditions.

It is not known if XYOSTED is safe and effective for use in children younger than 18 years old. Improper use of XYOSTED may affect bone growth in children.

It is not known if XYOSTED is safe or effective to treat men who have low testosterone due to aging.

XYOSTED is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Keep your XYOSTED in a safe place to protect it. Never give your XYOSTED to anyone else. Selling or giving away this medicine may harm others and it is against the law.

XYOSTED is not meant for use by women.

For more information, go to www.XYOSTED.com or call 1-844-XYOSTED (1-844-996-7833).
To report side effects to the FDA, visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see the full Prescribing Information and Medication Guide.
August 2025 Update.

Instructions for Use

Xyosted Instructions for Use PFD Page 1
Xyosted Instructions for Use PFD Page 2
Xyosted Instructions for Use PFD Page 3