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Get Prescription Triamterene-Hydrochlorothiazide Online

  • Fixed-dose combination medication
  • Treats high blood pressure and fluid retention
  • Sold under brand names Dyazide and Maxzide
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745,000+ Patients Served
What is triamterene-hydrochlorothiazide?

Triamterene and hydrochlorothiazide is a combination prescription medication used to treat high blood pressure (hypertension) and fluid retention (edema). It’s also known as co-triamterzide.

It pairs two different types of diuretics, or “water pills,” that work together to help your body get rid of excess salt and water while keeping important potassium levels in balance.

How does triamterene and hydrochlorothiazide work?

Triamterene and hydrochlorothiazide work together to reduce excess fluid in the body and help lower blood pressure by targeting how your kidneys handle salt and water.

  • Hydrochlorothiazide helps your kidneys remove sodium and water, which decreases blood volume and reduces blood pressure. However, it can also cause your body to lose potassium, an important mineral.
  • Triamterene helps your body retain potassium while still getting rid of excess fluid. This helps maintain a healthier electrolyte balance.

By combining these two medications, this treatment supports fluid control and blood pressure management with a lower risk of potassium depletion, a common side effect of many diuretics.

How do I know if I qualify for triamterene and hydrochlorothiazide?

You may qualify for triamterene and hydrochlorothiazide if you have high blood pressure or fluid retention – especially if you need a diuretic but are at risk for low potassium levels. A healthcare provider will determine if this combination is right for you by evaluating:

  • Your blood pressure readings or presence of swelling
  • Your electrolyte levels, especially potassium
  • Any other medications you're taking (to avoid interactions)
  • Your overall kidney function and medical history

This treatment isn’t right for everyone, especially if you have kidney problems or high potassium levels, so a provider will carefully review your case before prescribing it.

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Frequently
Asked
Questions

How do I know if triamterene-hydrocholorothiazide is right for me?

Triamterene-hydrochlorothiazide might be right for you if you need help managing high blood pressure or fluid retention, and you're at risk of low potassium from other diuretics. A healthcare provider will consider:

  • Your current blood pressure or symptoms of fluid buildup (like swelling in your legs)
  • Your potassium and kidney function levels
  • Any medications you're taking that could interact with diuretics
  • Whether you’ve had side effects with other water pills

If you need a diuretic but want to avoid dropping your potassium too low, this combo may be a good option – but only if it's safe based on your health profile. Your provider will help decide if it’s the right fit.

Does triamterene-hydrochlorothiazide cause weight loss?

Triamterene-hydrochlorothiazide may cause temporary weight loss, but it’s usually due to fluid loss, not fat loss. As a diuretic, this medication helps your body get rid of excess water and sodium, which can lead to a quick drop on the scale – especially if you’ve been retaining fluid due to high blood pressure or certain medical conditions.

However, this effect is not the same as true, long-term weight loss. Once your fluid levels stabilize, the weight often levels out as well. This medication is not intended or prescribed for weight loss, and using it for that purpose can be unsafe. Be sure to follow your provider’s guidance for how and why it should be used.

Can you take triamterene on its own?

Triamterene can be prescribed on its own, but it’s more commonly used in combination with other diuretics – like hydrochlorothiazide – to help manage blood pressure or reduce fluid retention while keeping potassium levels stable.

When used by itself, triamterene may be appropriate if:

  • You only need a mild diuretic
  • You’re at risk of low potassium
  • You're unable to tolerate other medications

However, it's generally not as effective alone for lowering blood pressure compared to when it’s paired with another diuretic. Your healthcare provider can help determine if monotherapy with triamterene makes sense based on your needs and lab results.

Can you take hydrochlorothiazide on its own?

Yes, hydrochlorothiazide (HCTZ) is often prescribed on its own – especially to treat high blood pressure or mild fluid retention. It’s a thiazide diuretic that helps the body get rid of excess sodium and water through urine, which can help lower blood pressure and reduce swelling. However, HCTZ can lower potassium levels, which is why it’s sometimes combined with a potassium-sparing diuretic like triamterene. Whether HCTZ is prescribed alone or in combination depends on your:

  • Electrolyte balance
  • Kidney function
  • Blood pressure goals
  • Risk of side effects like low potassium

A provider will monitor you closely and adjust your treatment as needed.

Does triamterene-hydrochlorothiazide cause ED?

While ED is not a common side effect of triamterene-hydrochlorothiazide, some men may experience changes in sexual function.

Hydrochlorothiazide, the thiazide component, has been linked to sexual side effects like reduced libido or ED in certain individuals. This may be due to its effects on blood flow, electrolyte balance, or testosterone levels. Triamterene is generally not known to worsen ED and is added mainly to help balance potassium.

If you notice changes in sexual function while taking this medication, be sure to speak with your provider. They may adjust your treatment or explore alternatives that better support both your cardiovascular and sexual health.

What medication(s) should not be taken with triamterene-hydrochlorothiazide?

Certain medications should be used with caution – or avoided altogether – when taking triamterene-hydrochlorothiazide, because they may increase the risk of side effects, especially high potassium, low blood pressure, or kidney issues. Common examples include:

  • ACE inhibitors (like lisinopril) and
  • ARBs (like losartan), which can raise potassium levels
  • Potassium supplements or high-potassium diets
  • NSAIDs (like ibuprofen or naproxen), which may reduce kidney function when combined with diuretics
  • Lithium, since diuretics can increase lithium levels and risk of toxicity
  • Other diuretics or blood pressure medications, which can intensify effects on blood pressure or electrolytes
What are the most common side effects of triamterene-hydrochlorothiazide?

The most common side effects of triamterene-hydrochlorothiazide include:

  • Increased urination
  • Dizziness or lightheadedness, especially when standing up quickly
  • Headache
  • Nausea
  • Muscle cramps or weakness
  • Electrolyte imbalances, such as high potassium (hyperkalemia) or low sodium
  • Fatigue

These side effects often improve as your body adjusts, but if you experience severe symptoms like irregular heartbeat, muscle pain, or swelling, contact your healthcare provider promptly.

Can LifeMD prescribe triamterene-hydrochlorothiazide?

Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe a medication and send it directly to your local pharmacy.

For even more flexibility, a LifeMD+ membership gives you 24/7 access to care, same-day prescription refills, exclusive wellness perks, and easy access to lab testing — all designed to make managing your health simple and stress-free.

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