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Valacyclovir is an antiviral medication used to treat infections caused by herpes viruses, including:
While it doesn't cure herpes, valacyclovir can help manage symptoms, speed up healing, and lower the risk of spreading the virus to others. Please note that chickenpox and herpes are not the same thing. Chickenpox is a contagious disease caused by the varicella-zoster virus. Herpes are types of viruses. The herpes-zoster virus can cause shingles and chickenpox, while the herpes simplex virus can cause cold sores and genital herpes.
Valacyclovir works by interfering with the virus’s ability to replicate. Once inside the body, it’s converted into acyclovir, the active form of the drug. Acyclovir targets the viral DNA replication process – essentially blocking the virus from multiplying.
By slowing the virus down, valacyclovir helps the immune system control the infection more effectively. This leads to shorter and less intense outbreaks, faster healing of sores, and in some cases, can prevent future outbreaks altogether when taken daily as suppressive therapy. It also helps reduce the risk of transmitting the virus to others.
You may qualify for valacyclovir if you’ve been diagnosed with a herpes virus infection – such as cold sores, genital herpes, or shingles – and your healthcare provider determines that antiviral treatment is appropriate.
You’re more likely to be prescribed valacyclovir if you:
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Valacyclovir may be right for you if you have a confirmed or suspected herpes virus infection and you're looking to manage outbreaks, reduce symptoms, or lower the risk of transmission. A licensed healthcare provider will consider your medical history, frequency of outbreaks, immune status, and overall health to decide if this antiviral is a good fit.
No, valacyclovir is not a controlled substance. It’s a prescription medication, but it’s not considered habit-forming and doesn’t have a risk of abuse or dependence. However, it should still be taken exactly as directed by your provider.
Valacyclovir typically starts working within 24 to 48 hours of your first dose – especially when taken at the first sign of symptoms like tingling, burning, or pain.
Everyone responds differently, but the earlier you start valacyclovir, the more effective it tends to be.
Valacyclovir can be taken during pregnancy if a healthcare provider determines that the potential benefits outweigh the risks. It’s typically prescribed to pregnant women with genital herpes, especially in the third trimester, to help prevent an outbreak during delivery and lower the risk of passing the virus to the baby. While research hasn’t shown clear evidence of harm to the fetus, the data is limited.
If you’re pregnant or planning to become pregnant, be sure to let your provider know before starting valacyclovir.
Yes, you can drink alcohol in moderation while taking valacyclovir, as there’s no direct interaction between the two. However, it’s best to use caution.
Both alcohol and valacyclovir can stress the liver and kidneys, so drinking heavily may increase the risk of side effects like dehydration, dizziness, or fatigue. If you’re feeling run down from an active viral outbreak, alcohol may also make it harder for your body to recover.
If you do choose to drink, be sure to stay well-hydrated and avoid overdoing it.
Yes, it’s still possible to get an outbreak while taking valacyclovir, especially if you’re using it only during active flare-ups (episodic treatment). The medication helps reduce the severity, duration, and frequency of outbreaks, but it doesn’t cure herpes or completely eliminate the virus from your body.
If you take valacyclovir daily as suppressive therapy, it significantly lowers the chances of getting an outbreak – but breakthrough episodes can still happen, particularly during times of stress, illness, or immune suppression.
Talk to your provider if you're still experiencing frequent outbreaks while on treatment – they may recommend adjusting the dose or switching to daily suppressive use.
Yes, valacyclovir is the generic form of Valtrex®. They contain the same active ingredient and work the same way in the body to treat herpes virus infections like cold sores, genital herpes, and shingles.
The main difference is that Valtrex is the brand name, while valacyclovir is the more affordable generic version. Both are equally effective when taken as prescribed.
The most common side effects of valacyclovir are generally mild and go away on their own. These may include:
Less commonly, some people may experience changes in mood, rash, or increased sensitivity to sunlight. Serious side effects are rare but can include confusion or kidney issues, especially in older adults or those with kidney problems. If you notice anything unusual or bothersome while taking valacyclovir, it's a good idea to check in with your healthcare provider.
Yes! With LifeMD, you can connect with a licensed healthcare provider from the comfort of your home within an hour. If appropriate, your provider may prescribe a medication and send it directly to your local pharmacy.
For even more flexibility, a LifeMD+ membership gives you 24/7 access to care, same-day prescription refills, exclusive wellness perks, and easy access to lab testing — all designed to make managing your health simple and stress-free.
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